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Scientific breakthrough may help save Tasmanian devils from bizarre, contagious cancer

December 31, 2009 |  4:27 pm

Taz2 Fierce as they are, Tasmanian devils can't beat a contagious cancer that threatens to wipe them out. Now scientists think they've found the disease's origin, a step in the race to save Australia's snarling marsupial.

The furry black animals spread a fast-killing cancer when they bite one another's faces. Since the disease's discovery in 1996, their numbers have plummeted by 70%. Last spring, Australia listed the devils -- made famous by their Looney Tunes cartoon namesake Taz -- as an endangered species.

There's no treatment and little hope of finding one until scientists better understand what's fueling this bizarre "devil facial tumor disease." So an international research team picked apart the cancer's genes and discovered that it apparently first arose in cells that protect the animals' nerves.

The surprise finding, reported in Friday's edition of the journal Science, has led to development of a test to help diagnose this tumor.

Next, scientists are hunting the mutations that turned these cells rogue, work they hope could one day lead to a vaccine to protect remaining Tasmanian devils, or perhaps treatments.

"The clock's ticking," lead researcher Elizabeth Murchison of the Australian National University said by phone from Tasmania. "It's awful to think there could be no devils here in 50 years because they're dying so quickly."

The devils, known for powerful jaws, fierce screeches and voracious consumption of prey, are the world's largest marsupial carnivores. They don't exist in the wild outside Tasmania, an island south of Australia.

What triggered this cancer, which causes tumors that grow so large on the face and neck that the animals eventually can't eat?

Tex a Tasmanian Devil reacts in his enclosure 
at Sydney's Taronga Zoo. It didn't jump from another species, said Murchison. Tasmanian devils, for unknown reasons, are prone to various types of cancer. This tumor's genetic signature suggests that probably no more than 20 years ago, mutations built up in some animals' Schwann cells -- cells that produce the insulation, called myelin, crucial for nerves -- and the first devil fell ill with this new type.

Those mutations went far beyond a typical cancer. When one sick animal bites another, it transplants living cancer cells that form a copy of the first animal's tumor. Murchison's team tested 25 tumors gathered from devils in different parts of Tasmania  and found the tumors were essentially identical to one another.

It's one of only two forms of cancer known to spread this way, Murchison said; the other is a sexually transmitted cancer in dogs. (That's quite different from people's transmission of a few cancer-causing viruses, including the human papillomavirus that causes cervical cancer.)

The researchers created a diagnostic test, based in part on a myelin-related protein called periaxin that was present in all the facial tumors but not in other cancers.

Also, the team compiled a catalog of Tasmanian devil genetic information. Among the next goals is to determine which of those genes most influence the spread and severity of this cancer.

-- Associated Press

Top photo: A Tasmanian devil at Healesville Sanctuary.  Credit: Cameron Wells / Walter and Eliza Hall Institute

Bottom photo: A Tasmanian devil reacts in its enclosure at the Taronga Zoo in Sydney.  Credit: Mark Baker / Associated Press

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