Wednesday's TV Highlights: Valerie Bertinelli gets the 'THS' treatment on E!
SPOKESWOMAN: A new edition of 'The E! True Hollywood Story' profiles actress-author Valerie Bertinelli (10 p.m. E!)
Mercy: A brave cancer patient inspires Veronica (Taylor Schilling) to face her fear of telling her husband (Diego Klattenhoff) about her affair with Dr. Sands (James Tupper) on a new episode of the hospital drama (8 p.m. NBC).
America's Next Top Model: Marisa Miller serves as a guest judge (8 p.m. KTLA).
Lock 'n Load: A young man volunteers to be tasered in this new episode (8 p.m. Showtime).
Criminal Minds: Rossi (Joe Mantegna) and the team try to track down a serial killer who collects the eyes of his victims. Salli Richardson-Whitfield returns as a victim's sister. With Thomas Gibson, Paget Brewster, Shemar Moore and Matthew Gray Gubler (9 p.m. CBS).
Modern Family: Manny (Rico Rodriguez) develops an interest in fencing, and he turns out to be good at it (9 p.m. ABC).
Tyler Perry's House of Payne: The situation comedy returns for a new season (9 p.m. TBS).
South Park: The town is overrun by obnoxious bikers during a Harley festival (10 p.m. Comedy Central).
Destination Truth: In the season finale, Josh Gates and his crew are in the small Himalayan nation of Bhutan in search of one of the most enduring and elusive legendary creatures ever: the migoi -- which you may know as the abominable snowman, yeti, sasquatch or Bigfoot (10 p.m. SyFy).
Flowers Uncut: This new unscripted series revolves around Jeff Leatham, a floral designer with a larger-than-life personality who specializes in big events and big names (10 p.m. TLC).
Johnny Mercer: The Dream's on Me: Music lover Clint Eastwood executive produced this affectionate profile of the affable, gap-toothed Georgian who penned the lyrics, music or both to some of the most beloved songs of the 20th century, including "Hooray for Hollywood," "On the Atchison, Topeka and the Santa Fe," "Moon River" and "Days of Wine and Roses." The special includes both extensive performance clips and archival interview footage (5 and 9 p.m. TCM).
Bill Cosby: The Mark Twain Prize 2009: A roster of top-flight American comics including Jerry Seinfeld and Chris Rock salutes the Emmy-winning actor as he becomes the recipient of the 12th Annual Mark Twain Prize for American Humor (8 and 9:30 p.m. KCET).
Top Chef All Stars Dinner: In this new special, Fabio Viviani, a fifth-season alumnus of the cooking competition, hosts a gathering of fellow "Top Chef" chefs (including Harold Dieterle, Ilan Hall, Hung Huynh and fan favorites Tiffani Faison, Marcel Vigneron, Dale Levitski, Casey Thompson, Richard Blais, Lisa Fernandes, Carla Hall and Stefan Richter) who reminisce about their experiences and face a new challenge (10 p.m. Bravo).
Baseball: World Series, Game 6: The Philadelphia Phillies visit the New York Yankees (4:30 p.m. Fox).
Basketball: The Miami Heat visit the Washington Wizards (4 p.m. ESPN); the Lakers visit the Houston Rockets (5:30 p.m. KCAL); the Dallas Mavericks visit the New Orleans Hornets (6:30 p.m. ESPN).
Photo: Astrid Stawiarz/Getty Images for Jennie Craig