TV This Week Prime: Oct. 4- 10.
SUNDAYAlex O'Loughlin's vampire detective drama "Moonlight" bit the dust a while ago, but now the actor is back for the medical drama "Three Rivers." Doctor, vampire . . . what's the difference? It still means long hours and lots of blood. (CBS, 9 p.m.)
MONDAY"The View's" Sherri Shepherd (below) does a little moonlighting of her own with the new sitcom "Sherri."Shepherd plays a recently divorced working mom looking to get her groove back. All together now: You go, girl! (Lifetime, 7 p.m. Also Tue-Fri.)
TUESDAYPublish or perish? That is the dilemma facing Charles Darwin as the science series "NOVA" presents "Darwin's Darkest Hour," a two-hour docudrama about the 19th century naturalist and his still-controversial theory of evolution. "Lost's" Henry Ian Cusick (above) stars. (KCET, 8 p.m.)
WEDNESDAYRemember NBC's "quarterlife"? Neither do we. But now, another Web series about the indignities of twentysomethingness makes the leap to TV with the debut of "Secret Girlfriend."The gimmick? The actors speak directly into the camera, making you, the viewer, the center of the action. With Sara E.R. Fletcher. (Comedy Central, 10:30 p.m.)
THURSDAYThe sweetest TV love match in many a season finally comes to fruition as Jim and Pam (John Krasinski, Jenna Fischer) tie the knot in a very special hour-long episode of "The Office."They've even invited their Dunder-Mifflin coworkers to the ceremony. On second thought, maybe they should have eloped. (NBC, 9 p.m.)
FRIDAYBrace yourselves, because Fridays are about to get ugly . . . "Ugly Betty," that is. The comedy, starring America Fererra (below) as everyone's favorite fledgling fashionista, premieres on its new night. The ugly part: "Betty" faces perennial time slot champ "Ghost Whisperer." (ABC, 8 p.m.)
SATURDAYThere's a whole lot of shakin' going on as Brittany Murphy and "ER's" Eriq La Salle star in the new made-for-cable disaster flick "Megafault." But this isn't your father's earthquake; it threatens to tear apart the whole continent! (SyFy, 9 p.m.)