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Lethal levels of propofol found in Michael Jackson's body, affidavit says [Updated]

MurrayL.A. County coroner's officials found lethal levels of the powerful anesthetic propofol after examining Michael Jackson's body, according to a search warrant affidavit unsealed today in Houston.

According to the search warrant, Jackson's doctor, Conrad Murray, told detectives with the Los Angeles Police Department that he had been treating Jackson for insomnia for about six weeks. He had been giving Jackson 50 milligrams of propofol every night using an intravenous line, according to the court records.

But Murray told detectives that he feared Jackson was forming an addiction and began trying to wean the pop star off the drugs. He lowered the dosage to 25 milligrams and mixed it with two other sedatives, lorazepam and midazolam. On June 23, two days before Jackson's death, he administered those two medications and withheld the propofol.

On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave Jackson valium at 1:30 a.m. When that didn't work, he said, he injected lorazepam intravenously at 2 a.m. At 3 a.m., when Jackson was still awake, Murray administered midazolam.

Over the next few hours, Murray said he gave Jackson various drugs. Then at 10:40 a.m., Murray administered 25 milligrams of propofol after Jackson repeatedly demanded the drug, according to the court records.

[Updated at 12:45 p.m.: Although Murray acknowledged to police that he administered propofol, authorities said they could find no evidence that he had purchased, ordered or obtained the medication under his medical license or Drug Enforcement Administration tracking number. However, police detectives saw about eight bottles of propofol in the house along with other vials and pills that had been prescribed to Jackson by Dr. Murray, Dr. Arnold Klein and Dr. Allan Metzger.

Other drugs that were confiscated in the search included valium, tamsulosin, lorazepam, temazepam, clonazepam, trazodone and tizanidine. They also found propofol in Murray’s medical bag. Murray told detectives that he was not the first doctor to administer the powerful anesthetic to Jackson.

At least two unidentified doctors gave Jackson propofol in Germany. Between March and April 2009, Murray said he called Las Vegas doctor David Adams at Jackson’s request to arrange for Adams to administer propofol. Murray said he was present at a cosmetologist’s office, where Adams used propofol to sedate Jackson. Since he began treating Jackson, Murray said he repeatedly asked the pop star what other physicians were treating Jackson and what drugs they were prescribing. But Jackson declined to provide the information, Murray told authorities.

Murray said he noticed injection marks on Jackson’s hands and feet. When he asked Jackson about them, the pop star told him he had been given a “cocktail” to help him. In addition to Murray, authorities subpoenaed medical records from Dr. Arnold Klein, Dr. Allan Metzger and Dr. David Adams, the affidavit states. They also asked for medical records from Dr. David Slavitt, who conducted the independent medical examination of Jackson for Anschuntz Entertainment Group, Dr. Randy Rosen and nurse practitioner Cherilyn Lee. They also subpoenaed records from Dr. Mark Tadrissi, who stored medical records with Adams. ]

Murray has already acknowledged obtaining and administering propofol to Jackson the morning that the pop star died. In an interview with police, Murray told them that he had left Jackson alone under the influence of the medication to make telephone calls to his Houston office and family members.

When he returned, he discovered Jackson was not breathing. He performed CPR, and one of Jackson’s staff members called 911. The 50-year-old pop star was rushed to the UCLA Medical Center, where he was later declared dead. Much of the investigation has focused on propofol — a drug typically administered by anesthesiologists during surgery — and whether Murray’s decision to give it to Jackson as a sleep aid outside a hospital setting reaches a level of negligence required for an involuntary manslaughter charge.

-- Kimi Yoshino

Photo: Conrad Murray. Credit: AFP / Getty Images

Interactive timeline: Michael Jackson | 1958-2009

Comments () | Archives (101)

So 25 mg is a lethal dose of Propofol for someone MJ's size?

Dr. Murray is a STUPID QUACK of a Doctor and I don't believe him. Michael Jackson already knew that other drugs did not work to put him to sleep, so why would he allow Dr. Murray to give them to him? Also, why would a Dr. continue to give you a variety of drugs within hours of each other? Hasn't this STUPID Dr. heard that drugs can interact with each other with devastating effects. STUPID, STUPID, QUACK, QUACK, DOCTOR. I don't believe Michael would have allowed all those different types of drugs to be given to him at once. Michael was use to taking various drugs and would have known what to take and not to take together. Oh, by-the-way, blame it on Jackson, The doctor gave it to him after he demanded it, no, you were only thinking about your pockets.

This is a bit confusing to me. I thought they had showed that when the ambulance arrived, LIVIDITY had settled in, so he was dead for more than an hour. With the 10:40 admin of Propofol, this doesn't make chronological sense anymore....

Did this doctor ever even consider trying something like valarium tea, or maybe even warm milk? Meditation? Soothing music? Hypnosis?

Hang Murray Higher And The People Behind Him HIGHEST !!!

Sad for his children. They are the biggest losers from day one.

Bye Bye Dr. Murray

What a shame, now this doctor will go to prison for giving into the whims of his celebrity and spoiled client. It's like whatever Lola wants Lola gets type scenario and she died of her want.
It's all about in hindsight how this doc should have just stopped trying to get him to sleep, my god. How disparate we get when we can't go to sleep.

Poor MikeJack. No man can withstand all of those drugs. I do not think the doctor did it on purpose but it was very poor judgment. Still hard to believe. RIP homie.

Please arrest Conrad Murray. This desperate doctor killed Michael Jackson.

This man might as well kiss his medical license good bye as well as all that were involved in his medical care.

What a shame that no one took the time to look at MJ and noticed how sick he was. Someone should have been brave enough to step in and tell his mother, tell anyone who could stop this from continuing. i am still heart broken.

With all due respect, Michael Jackson was responsible for his own drug use. he was not that stupid.

No matter what came before, or how famous-a brilliant light lost in this way is tragic. RIP Michael, and may your children grow up remembering your brilliance-instead of the darkest nights.

Does that mean he is still dead?

Simply unbelievable! The doctor admininistered enough sedatives alone to be considered neligent, let alone the propofal. No reasonable or responsible doctor could rationalize what he gave MJ. Then to top it off with propofal! He should get the full thrust of the law and I hope he rightly gets charged with at least manslaughter if not murder. One has to ask how a doctor would not know what might constitute a "lethal" dose. Perhaps LaToya was right! I am no doctor but at some point, common sense should kick in, but apparently Dr. Conway only has credentials and a fat monthly cheque from MJ....and no common sense. A loss of life that now can be fully attributed to one man - Dr. Conway! Hope he gets what he damn well deserves!

So he died from Propofol? Seems more like the cocktail of drug is what killed him. I guess if they found a 'lethal' amount of Propofol that would technically be the case of death though. What a shame.

Thank you a lot Mr "doctor", great job... Poor sweet Michael I love you.

This is really outrageous that an MD would give a patient 3 tranquillizers followed by "various drugs" followed by propofol. This guy is dangerous! I also do not believe he waited till 10:30 am to start the propofol or that he was worried about MJ getting addicted to it since it is not addicting but the other meds are. He is trying to cover up something here. Great investigative work! We need more journalists like you!

Investigate this Tohme guy too. Something is very fishy going on with him. MJ was afraid of him.

This is heartbreaking. Poor Michael. RIP.

Muray's story still sounds hinky. Why would he not do lab work and review prior medical records like most doctors do.

Why would he keep giving medications one after another just because a patient asks for it. What a quack!

I am still going to wait on the autopsy results because there is just so many stories out there.

Michael Jackson is getting a good sleep now!

are they sure this is michael jackson's body? i mean really sure? a lot of us wonder. did they ever test for that? where was his body guard? he was suppose to protect him. i believe it was his staff who did all them drugs not michael. if it is michael. i got bad feelings it is not him. also murrey had cell phone why did he need to leave him... ? cause he is covering his own butt. he is more worried about his reputation then michael.. had the nerve to make a vedeo...
he is guilty and a killer.. arrest him.. or society is gonna wonder why society meaning all his fans. throwing in psych drugs above theriputic levels is murder and mixing them up too. omg he is nuts...
i dont believe for a moment michael with three beautiful children he loves so much would do drugs like media states. all storyes big money. omg media has slammed michael so bad... and that is not him.. i am heart sick over all this...

It´s sooo sad ... I don´t want to blame just Dr.Murray, but ... how could a physician rely on info from his patient?! No one can. I think it´s a must for any attending physician to first "get acquainted" with his/her client´s health history, anamnesis, make a thorough examination, tests of blood, urine .... Otherwise it is a negligence. Seems to me that all the "doctors" were just taking advantage of Michael. ´Money, money, money´ - instead of Hippocratic Oath, a moral of conduct: "I will prescribe regimens for the good of my patients according to my ability and my judgment and never do harm to anyone...."

This is the very definition of negligent homicide, or at the very least manslaughter. Just how many drugs did this QUACK give MJ?

I'm crying all over again. MJ predicted that he would die in the same manner that Elvis did--and Elvis died because of an overdose of a whole bunch of drugs! Michael may have not taken the drugs himself, but through this doctor he might as well have done the deed himself.

You beautiful, beautiful soul!! You didn't have to die like this!! You didn't have to leave your CHILDREN like this!! I want to start this summer over again, back before the doctor started giving him that lethal cocktail of drugs, then LEFT HIM ALONE IN THE ROOM, UNSUPERVISED!! **soooooo angry right now**

Just throw the book at Dr. Murray. He's so done, it's not even funny.

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