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'Lethal levels' of anesthetic propofol killed Michael Jackson

Murray

Michael Jackson died of "lethal levels" of the powerful anesthetic propofol, according to a search warrant affidavit unsealed today in Houston.

The court documents quote the L.A. County coroner's office as reaching that conclusion after an autopsy of the pop star.

The documents address one of the major unanswered questions surrounding Jackson's death. But they also raise new questions about how Jackson was treated, particularly in the hours before his death.

Conrad Murray, Jackson's personal doctor, told detectives with the Los Angeles Police Department that he had been treating Jackson for insomnia for about six weeks. He had been giving Jackson 50 milligrams of propofol every night using an intravenous line, according to the court records.

But Murray told detectives that he feared Jackson was forming an addiction and began trying to wean the pop star off the drugs. He lowered the dosage to 25 milligrams and mixed it with two other sedatives, lorazepam and midazolam. On June 23, two days before Jackson's death, he administered those two medications and withheld the propofol.

On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave Jackson valium at 1:30 a.m. When that didn't work, he said, he injected lorazepam intravenously at 2 a.m. At 3 a.m., when Jackson was still awake, Murray administered midazolam.

Over the next few hours, Murray said he gave Jackson various drugs. Then at 10:40 a.m., Murray administered 25 milligrams of propofol after Jackson repeatedly demanded the drug, according to the court records.

Although Murray acknowledged to police that he administered propofol, authorities said they could find no evidence that he had purchased, ordered or obtained the medication under his medical license or Drug Enforcement Administration tracking number. However, police detectives saw about eight bottles of propofol in the house along with other vials and pills that had been prescribed to Jackson by Dr. Murray, Dr. Arnold Klein and Dr. Allan Metzger.

Other drugs that were confiscated in the search included valium, tamsulosin, lorazepam, temazepam, clonazepam, trazodone and tizanidine. They also found propofol in Murray’s medical bag. Murray told detectives that he was not the first doctor to administer the powerful anesthetic to Jackson.

At least two unidentified doctors gave Jackson propofol in Germany. Between March and April 2009, Murray said he called Las Vegas doctor David Adams at Jackson’s request to arrange for Adams to administer propofol. Murray said he was present at a cosmetologist’s office, where Adams used propofol to sedate Jackson. Since he began treating Jackson, Murray said he repeatedly asked the pop star what other physicians were treating Jackson and what drugs they were prescribing. But Jackson declined to provide the information, Murray told authorities.

Murray said he noticed injection marks on Jackson’s hands and feet. When he asked Jackson about them, the pop star told him he had been given a “cocktail” to help him. In addition to Murray, authorities subpoenaed medical records from Dr. Arnold Klein, Dr. Allan Metzger and Dr. David Adams, the affidavit states. They also asked for medical records from Dr. David Slavitt, who conducted the independent medical examination of Jackson for Anschutz Entertainment Group, Dr. Randy Rosen and nurse practitioner Cherilyn Lee. They also subpoenaed records from Dr. Mark Tadrissi, who stored medical records with Adams.

Jackson’s doctor told authorities he left Jackson’s bedside for no more than two minutes before returning to find the pop star not breathing. Jackson reportedly fell asleep at 10:40 a.m.
 
Murray said after monitoring Jackson for 10 minutes, he left to use the restroom. When he returned and saw Jackson wasn’t breathing at 11 a.m. He immediately began attempting to revive Jackson, administering CPR as well as a drug to reverse the effects of the sedative. But police are questioning that account. Cellphone records for the morning of June 25 show Murray made three separate phone calls for approximately 47 minutes beginning at 11:18 a.m.
 
He called Jackson’s personal assistant to request that they send security upstairs. After a few minutes without a response, Murray told authorities he ran downstairs to the kitchen. He asked the chef to send Jackson’s eldest son, Prince Jackson, upstairs. Murray said he continued CPR and waited for the arrival of paramedics.

Murray has already acknowledged obtaining and administering propofol to Jackson the morning that the pop star died. In an interview with police, Murray told them that he had left Jackson alone under the influence of the medication to make telephone calls to his Houston office and family members.

When he returned, he discovered Jackson was not breathing. He performed CPR, and one of Jackson’s staff members called 911. The 50-year-old pop star was rushed to UCLA Medical Center, where he was later declared dead. Much of the investigation has focused on propofol -- a drug typically administered by anesthesiologists during surgery -- and whether Murray’s decision to give it to Jackson as a sleep aid outside a hospital setting reaches a level of negligence required for an involuntary manslaughter charge.

-- Kimi Yoshino and Andrew Blankstein

Photo: Conrad Murray. Credit AFP / Getty Images

 
Comments () | Archives (213)

Someone has to be the scapegoat. The DOC is going to go to jail.

I think to blame Michael Jackson is shameful. He was an addict and it's up to the doctor to take responsibility for treating their patients. Obviously, after years of being addicted, this weaning off prescriptions drugs were not going to happen overnight. His death could have been provided,

An MD with a $150,000 per month payment surely was being just a lackey handmaiden to Michael Jackson's entreaties for the addicted drug that he used "Propofol" Diprivan,Did the Coroner's Pathologist Report show any other drug residues than the "lethal levels of Propofol ? that Dr.Conrad Murray allegedly gave Michael Jackson who under addiction is basically a child incapable of rational or sound judgment of his own needs to be healthy,that's why Doctors of Medicine are for to treat addiction,not give in to addiction! GCW Heng Sr.

GCW Heng SR.

Sure Anesthetic drugs can be lethal. There are many suicides in the operating rooms, especially those who have access to pharmacies,physicians, anesthesiologists and nurses. ( evans, glen 2003 ) Euthanasia is an other issue : Does Michael Jackson knew he was sick and has not a long time to live ? Did he wanted to finish with life? Was he right to choose the means. These are issues we can discuss, and laws are different, from a country to another. Also, people are innocent until proven guilty. It is not because he is a doctor that he should not benefit from that. But, if it comes that he is guilty, I do agree, justice should be harsh. Last but not least, I fear some trial by mob, everyone talking about costly health plan...being a doctor won't be easy in the coming weeks... mohammed suerte bennani. Author and Surgeon. Casablanca. http://www.suertebennani.com

Negligence- that's the term I was looking for.

The doctor was negligent. That drug is only suppossed to be given in a hospital setting. So right there the doctor was fully aware that what he was doing was wrong.

No good...the doctor broke his oath for money. Now a person is dead b/c a doctor was greedy and put dollar signs before a person's well being.

The doctor is one hundred percent at fault.

If this is true, I sure hope there if true justice for Michael. Alot of people sayng "Michael brought this on himself." Michael was a man that appeared to suffer from major depression, anxiety and severe insomnia, I'm sure that impaired his logic and reasoning.

In my opinion, Just the fact: This "doctor" gave him multiple drugs thoughout the night,(which slow the respitory system, then gave him Propofol and then left him alone. For that alone, he is negligent.

I have grown-up during the fifties and sixties. I've lost count how many rock/pop stars have died because of drugs. Damm, what a waste.

If Dr. Murray found MJ not breathing at 11am, why did it take so long to have some one call 911? I know he was giving CPR, but if it's not working, why would you wait? Every minute counts. The other question, is why was he doing CPR on the bed?

When I go to a Doc, I'm depending on them when they give me a prescription, that I'm not gonna die from taking it. Yes, MJ knew what he was taking, and what is really sad is, that it sounds like if you did not agree with MJ, you were gone, which is so unfortunate. All he wanted to do was sleep. I totally agree with the person that said "the pressure took his life", but it was with the help of not only Dr. Murray, but with the help of the other Doctors who treated him as well.

This has got be a living nightmare for MJ's mom. My thoughts and prayers are with her, the family, and MJ's children.

Wow! Very sad in deed! I guess this is the true meaning of "We'll sleep when we are dead!" MJ should have been treated for addiction. Not treated with drugs to cover the pain that kept him there. His family should all cash in on the cow now. Hope those kids find peace in their own way.

The relationship in a doctor and patient relationship is that the doctor is the responsible person. It is the doctor who has been trained in drug pharmacology, not the patient. Try stopping your hateration of Michael Jackson long enough to realize what you are posting. It is not alright for a doctor to get away with murdering his patient. God forbid your doctor kills you.

There are 50 million total reasons why MJ did not just say NO; 150,000 reasons per month why the Doc couldn't just say no; 500 million + why AEG couldn't just say "NO."

In the end, we have a group of physicians who spat at the Caduceus and sold their souls to the devil. But they are not alone ! His family could have intervened, but it must be difficult when you're living in a house that he bought.

Michael is the one to blame in the end! He got everything that money could buy. Including People who were subservient to him. None of them, including the "Nanny" could say "NO." She came back for a second stint, even after he fired her and she decided to "tell all" then retract it! Let's not forget the fans! If they knew his illness, would they have told him "NO?' Or would they have called him Wacko-Jacko and request their money back?

There is guilt-a-plenty here. In the end it was all about GREED! On everyone's behalf - The Doctors, AEG, The Family, Friends , fans and more ....MICHAEL.

MJ, you were the best of all time! RIP.

Clearly the doctor was negligent...But, it's also quite evident that Jackson has been playing fast and loose with drugs for some time now...If this wasn't Michael Jackson we're talking about here...He would be called by another name....Junky!

So, let's get this straight ..

1.30am - Valium
2.00am - Lorazepam (intravenously)
3.00am - Midazolam
Various drugs (?) for the next few hours
10.40am - 25 milligrams of propofol

Drug problem, much???

MJ always got his own way, with everyone. This is more like a suicide than homocide.

Everyone is at fault, and the unlucky alive person is the MD at the moment. Yes, it is also due to $$. However, you can't determine who is at fault. MJ is dead now, and the kids are literally orphans... except for Debbie Roe... who carried them to delivery.
Let's all let this rest in peace, as MJ is doing now.
The story is if we all stopped using Rx drugs that altered our senses, the drug companies might find cures for diseases such as diabetes, lowering high blood pressure, lowering our HDL and LDL... and then even cures for AIDS and Cancer!

His doc won't accept with composure
The coroner's newest disclosure:
He gave Mike a medley
Of dope that was deadly
And killed him with overexposure.

News Short n' Sweet by JFD8
http://twitter.com/JFD8

...One last question to Dr. Murray. Where in Medical School training, Residency or your practice did you ever use Propofol? Even in the Cath lab, you wouldn't have given it! So how can you give it in a freaking bedroom, without monitors? Did you have a Bag-And-Valve to give oxygen? An AED? Narcan? Sublimaze? Anything?

$150,000 per month? Chance of a Lifetime? Think! Why did you get into medicine? To practice good health care (which you were doing in Texas) or to become the Court Jester to MJ?

My thoughts. I believe you became starstruck! Big Time! Even when he stopped breathing, you said to yourself "What? No way, this cannot be happening?" With adrenaline running, you forgot about the basics. Administered CPR on a bed... Freaked Out! Anyone would have. If you look back at it, the time to have called 9-11 was when you noted the faint heartbeat or when you noticed he had stopped breathing. You're a Cardiologist, you know this. 100% NRB, AED, etc.

Personally, I don't hold you personally liable. What happened to the greatest entertainer of our generation was a collection of many years of "stuff!" Unfortunately, you ended up in one of those "chance of a lifetime" moments that backfired.

"Murray said after monitoring Jackson for 10 minutes, he left to use the restroom. When he returned and saw Jackson wasn’t breathing at 11 a.m. He immediately began attempting to revive Jackson, administering CPR as well as a drug to reverse the effects of the sedative. But police are questioning that account. Cellphone records for the morning of June 25 show Murray made three separate phone calls for approximately 47 minutes beginning at 11:18 a.m."

I believe Dr. Murray was calling to receive his orders as to what he was to do next.
The death of Michael Jackson is a murder conspiracy involving multiple people.

Incredible accounts of the events preceding MJ death. Sad that we lost such a talented person. Society is really to blame, we glorified him, put the man on a pedestal, he earned lots of money, and he felt invincible. The end result is that no one could treat MJ, we would doctor shop until he found doctors who would give him whatever he wanted for money. Michael was a drug addict that needed help badly, but he needed to admit to his problem to ask for help, instead he demanded drugs and got them. There will always be doctors out there that will give people drugs for the money, there are many out there that probably refused to get paid by MJ for drugs. MJ knew who to ask and demand it from. Having said all that I, know these doctors will get the death penalty and they deserve it. No amount of money should cloud your medical ethics and the correct treatment of a patient. They should all be punished. At the same time, let us not forget that although MJ was a great entertainer, he was a drug addict, and a demanding drug addict at that. MJ needed counselling and anti-depressants. Never heard of giving a potent muscle paralyser and leaving the patient to go to the bathroom or make phone calls. It's like being in the operating room under the anesthetic with ECG monitoring and the anesthesiologist says oh, I got to pee. Sorry. That is negligence period.

Money and power will be the cause of the end of humanity on this planet

We know there are millions of Americans who can glean all kinds of drugs to use and abuse.

The obvious fact that MJ used his celebrity and money to get the strong drugs that he wanted shouldn't be forgotten before we all jump on this POOR SAP
Dr Murray. MJ liked to be "knocked out" in way most of us cannot imagine.

"Insomnia"? Gimme a break! What MJ called "sleep" is a condition most human beings could happily have had their teeth removed!

I know the legal system will crucify this Dr Murray but if it wasn't Murray it would have been someone else or MJ himself administering this kooky drugs. Murray could NOT have denied MJ these drugs any more than his fans could resist his moonwalk.


Mrs Katherine Jackson

I hope this man rotts in jail. I hope they eat him up
Alive in prison he's a loser!!!!!!!!!!!!!!!!!!!!!!!!!

$$$$$ took his life. Either by himself or by the hands of those so-called "Friends". He spent it freely and so did those people that he paid to do his bidding. That Dr. filled him up with drugs instead of taking him to a hospital before it got as bad as it did. He did it for $$$$$$$$$$$$$$$$$$$. And so does everyone else in Hollywood. You all kiss ass if you can make a dollar, even if it means someone has to die.

I cannot for the life of me understand why in the world anyone in their right mind...doctor or not, would not call 911 when a person is not breathing? Instead, the patient isn't breathing and he opts to run to get a 12 year old child and talk on the cell phone for 45 minutes!!! Micheal may have asked to receive the drugs to relieve him of his insomnia...but he did not ask to be mistreated. The doctor made the wrong moves as far as I am concerned! 911 was called way too late!

I think avanza on its own would have been a better option than the the alleged coctail provided by Dr Murray if this article is true to the coroners report

http://sleep-disorders.suite101.com/article.cfm/the_man_who_never_slept

Why do so many people judge others without even knowing the truth?
It was very clear that Michael Jackson had suffered for years with sleep
deprivation. Yes he had gone to extra ordinary steps to find relief. For patients that have the above condition, they suffer greatly..... until finally falling asleep...FOREVER.... Please do not judge others unless you have walked in their shoes.
We never know how far we would go ....to find relief for ourselves and our loved ones. I'm not saying that Michael Jackson had this. I am saying that no one ever bothered to give him the benefit of the doubt...... I wish....someone was listening to his cries for help.....Such a great loss....for all.

 
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