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Diabetics should not take high doses of vitamin B, researchers say

April 28, 2010 |  5:59 pm

Diabetics with kidney disease who are taking high doses of B vitamins in an effort to forestall heart attacks should stop taking them immediately because they are potentially very harmful, Canadian researchers reported Tuesday in the Journal of the American Medical Assn. Rather than reducing the risk of heart attack and stroke, the vitamins appear to actually increase it, the researchers said.

An estimated 21 million Americans and 3 million Canadians have either Type 1 or Type 2 diabetes, and it is thought that at least 40% of them will develop diabetic nephropathy, in which the function of the kidneys is impaired. Diabetics typically have above-normal levels of the amino acid homocysteine in their blood, and elevated levels are associated with an increased risk of heart disease. B vitamins normally reduce homocysteine levels, and researchers had also though they would improve kidney function.

A team headed by Dr. David Spence of the University of Western Ontario in London organized a clinical trial in which researchers hoped to demonstrate a benefit from the supplement. They enrolled 238 diabetic patients at five Canadian medical centers. Half received a daily dose of 2.5 milligrams of folic acid, 25 milligrams of vitamin B6 and 1 milligram of vitamin B12 and half received a placebo.

After an average of 32 months, the researchers found that those taking the vitamins had a significantly higher decrease in kidney function, as measured by the  ability to filter toxic wastes from the bloodstream. Moreover, eight people taking the vitamins suffered a heart attack, compared with four taking the placebo; and six taking the vitamins suffered a stroke, compared to one taking the placebo. Spence said he was greatly surprised by the results and initially thought that researchers had mixed up the data. He noted that the vitamins are normally excreted in urine and speculated that kidney damage produced by the diabetes led to a toxic buildup of the supplement in the patients. The B vitamins included in multivitamin supplements should not be a problem, he added.

He said that researchers would have to find a different way to reduce homocysteine levels.

The study was funded by the Canadian Institutes of Health Research and the Kidney Foundation of Canada. The vitamins and placebos were donated by Pan American Laboratories.

-- Thomas H. Maugh II

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Comments (3)

Contrary to the LA Times' inaccurate headline, the researchers DID NOT say that "diabetics should not take high doses of vitamin B." They said that diabetics WITH KIDNEY FAILURE should not take high doses of vitamin B.

According to the University of Western Ontario, which conducted the study, "Vitamin B therapy may still be beneficial in people with normal kidney function."

http://communications.uwo.ca/com/western_news/stories/research_warns_against_common_diabetes_treatment___20100429446265/

And yet, diabetes 2 drug manufacturers are outlawing pyridoxamine B6 as a prescription drug, because they know it works.

The test is already flawed. They would all need to have the same type of diabetes, eat the same diet, do the same amount of exercise, have the same A1c for it to be accurate.
Also I bet most of them are already extremely unhealthy to begin with so its no surprise that some of them had heart attacks and strokes.

Oh ya I'm sure its the vitamins giving them heart attacks and strokes. And way to do a research study and then "speculate that kidney damage produced by the diabetes led to a toxic buildup of the supplement in the patients." You do the research studies so you don't have to speculate things, you prove them.

All this study showed was people who have diabetes and don't manage it get heart attacks and strokes.



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